Davies T F
Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029.
Mt Sinai J Med. 1992 Sep;59(4):326-34.
Graves' disease is a common, familial, but easily treated condition caused by unique autoantibodies which act as TSH agonists. Patients with the diagnostic eye signs of Graves' disease, however, require more careful treatment than those patients with principally thyroidal involvement because destructive therapy to the thyroid gland may exacerbate the eye disease. The cause of ophthalmic eye disease appears to be "crossover specificity" by the immune system for a recurrent antigen in extraocular muscles, fibroblasts, and the thyroid gland. Treatment directed at the autoimmune response may offer the most appropriate therapy in the years to come.
格雷夫斯病是一种常见的、具有家族性但易于治疗的疾病，由作为促甲状腺激素激动剂的独特自身抗体引起。然而，患有格雷夫斯病诊断性眼部体征的患者，比主要累及甲状腺的患者需要更谨慎的治疗，因为对甲状腺的破坏性治疗可能会加重眼部疾病。眼病的病因似乎是免疫系统对眼外肌、成纤维细胞和甲状腺中一种复发抗原的“交叉特异性”。针对自身免疫反应的治疗可能在未来几年提供最合适的疗法。
