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2
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引用本文的文献

1
THE ROLE IN ANAPHYLAXIS OF A CHYMOTRYPSIN-LIKE ENZYME IN RAT MAST CELLS.大鼠肥大细胞中一种类胰凝乳蛋白酶在过敏反应中的作用
Immunology. 1963 Sep;6(5):478-83.
2
Effect of anoxia, glucose and thioglycollate on anaphylactic and compound 48/80-induced histamine release in isolated rat mast cells.缺氧、葡萄糖和巯基乙酸对离体大鼠肥大细胞中过敏反应及化合物48/80诱导的组胺释放的影响。
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3
Oxygen consumption during histamine release by antigen and compound 48/80.抗原和化合物48/80释放组胺过程中的氧消耗
Immunology. 1965 May;8(5):511-8.
4
The isolation from spleen tissue of high molecular weight proteins which alter vascular permeability: investigation of their pharmacological properties.从脾组织中分离出可改变血管通透性的高分子量蛋白质：对其药理特性的研究。
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5
Inhibition of the release of mediators of immediate-type allergy in vivo and in vitro.体内和体外抑制速发型过敏介质的释放。
Proc R Soc Med. 1973 Dec;66(12):1191-8. doi: 10.1177/003591577306601221.
6
Human antibodies to mast cells.针对肥大细胞的人类抗体。
Clin Exp Immunol. 1973 Jul;14(3):327-34.
7
The effect of phospholipids on anaphylactic histamine release.磷脂对过敏性组胺释放的影响。
Br J Pharmacol. 1972 Dec;46(4):741-52. doi: 10.1111/j.1476-5381.1972.tb06899.x.
8
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Immunology. 1971 Nov;21(5):729-39.
9
Histamine and its metabolism in mammals. Part II: Catabolism of histamine and histamine liberation.组胺及其在哺乳动物体内的代谢。第二部分：组胺的分解代谢与组胺释放
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10
Pharmacologic modulation of inflammatory mediator release by rat mast cells.大鼠肥大细胞对炎症介质释放的药理学调节
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Further observations on the disruption of rat mesentery mast cells caused by compound 48/80, antigen-antibody reaction, lecithinase A and decylamine.关于化合物48/80、抗原-抗体反应、卵磷脂酶A和癸胺对大鼠肠系膜肥大细胞破坏作用的进一步观察
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Anaphylaxis in chopped guinea pig lung. I. Effect of peptidase substrates and inhibitors.豚鼠肺切碎物中的过敏反应。I. 肽酶底物和抑制剂的作用。
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一种类胰凝乳蛋白酶在大鼠肥大细胞组胺释放中的作用

THE ROLE OF A CHYMOTRYPSIN-LIKE ENZYME IN HISTAMINE RELEASE FROM RAT MAST CELLS.

作者信息

PERERA B A, MONGAR J L

出版信息

Immunology. 1963 Sep;6(5):472-7.

PMID:14069724
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423278/
Abstract

The presence of a chymotrypsin-like enzyme in rat mast cells has been confirmed, and it has been shown that intact mast cells contain the fully activated enzyme without losing their histamine content. It has been shown by means of inhibitors that the chymotrypsin-like enzyme is distinct from the heat-labile SH enzyme required for the histamine releasing action of compound 48/80. The synthetic ester used as a substrate for chymotrypsin released histamine from rat mast cells probably by a non-enzymic reaction.

摘要

已证实大鼠肥大细胞中存在一种类胰凝乳蛋白酶，且已表明完整的肥大细胞含有完全活化的该酶，同时不会损失其组胺含量。通过抑制剂已表明，类胰凝乳蛋白酶不同于化合物48/80组胺释放作用所需的热不稳定巯基酶。用作胰凝乳蛋白酶底物的合成酯可能通过非酶促反应从大鼠肥大细胞中释放组胺。