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本文引用的文献

1
THE ROLE OF A CHYMOTRYPSIN-LIKE ENZYME IN HISTAMINE RELEASE FROM RAT MAST CELLS.一种类胰凝乳蛋白酶在大鼠肥大细胞组胺释放中的作用
Immunology. 1963 Sep;6(5):472-7.
2
Anaphylaxis in chopped guinea pig lung. I. Effect of peptidase substrates and inhibitors.豚鼠肺切碎物中的过敏反应。I. 肽酶底物和抑制剂的作用。
J Exp Med. 1961 Mar 1;113(3):521-39. doi: 10.1084/jem.113.3.521.
3
Effect of diisopropylfluorophosphate on sulfhydryl proteases.二异丙基氟磷酸酯对巯基蛋白酶的作用。
Science. 1959 Jun 19;129(3364):1678. doi: 10.1126/science.129.3364.1678.
4
Effect of temperature on the anaphylactic reaction.温度对过敏反应的影响。
J Physiol. 1957 Feb 15;135(2):320-38. doi: 10.1113/jphysiol.1957.sp005713.

大鼠肥大细胞中一种类胰凝乳蛋白酶在过敏反应中的作用

THE ROLE IN ANAPHYLAXIS OF A CHYMOTRYPSIN-LIKE ENZYME IN RAT MAST CELLS.

作者信息

PERERA B A, MONGAR J L

出版信息

Immunology. 1963 Sep;6(5):478-83.

PMID:14069725
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1423279/
Abstract

The role of a chymotrypsin-like enzyme in the release of histamine in anaphylaxis has been investigated using sensitized rat peritoneal mast cells. Inhibition of this enzyme did not inhibit histamine release and, conversely, when histamine release was blocked the esterase activity was unaffected. It is concluded that the active chymotrypsin-like enzyme in these cells is not involved in the anaphylactic reaction. One of the inhibitors used (DFP) produced a dual action on histamine release. A possible explanation is discussed.

摘要

利用致敏大鼠腹膜肥大细胞研究了类胰凝乳蛋白酶在过敏反应中组胺释放过程中的作用。抑制这种酶并未抑制组胺释放，相反，当组胺释放被阻断时，酯酶活性未受影响。得出的结论是，这些细胞中具有活性的类胰凝乳蛋白酶不参与过敏反应。所使用的一种抑制剂（二异丙基氟磷酸）对组胺释放产生了双重作用。文中讨论了一种可能的解释。