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[静脉主动脉冠状动脉搭桥手术的长期效果真的那么差吗?对428例患者进行的为期13年的前瞻性研究]

[Are the long-term results of venous aortocoronary bypass procedures really so bad? A prospective 13-year-long study of 428 patients].

作者信息

van Brussel B L, Plokker H W, van den Bergh E J, Ernst J M, Knaepen P J, Vermeulen F E

机构信息

Afd. Cardiologie, St. Antonius Ziekenhuis, Nieuwegein.

出版信息

Ned Tijdschr Geneeskd. 1992 Oct 17;136(42):2072-7.

PMID:1407209
Abstract

OBJECTIVE

To assess the long-term results of coronary surgery using venous bypasses.

DESIGN

Prospective study.

SETTING

St. Antonius Hospital, Nieuwegein, the Netherlands.

METHOD

In 446 successive patients subjected to coronary surgery between 1 April 1976 and 1 April 1977, a complete long-term follow-up study was carried out after an average of 11.5 years (1.5 months-14.3 years).

RESULTS

The peroperative mortality was 3%, a peroperative myocardial infarction occurred in 6.3% and complete revascularization was achieved in 77.6% of the patients. In 90 of 100 patients selected at random, cardiac catheterization was performed 13.5 months on average after the operation. The patency of the single grafts was 89.8%, that of the side-to-side and end-to-side anastomoses of the sequential grafts was 90.4% and 83%, respectively. Mortality, myocardial infarction, necessity of a second operation and angina pectoris occurred with low frequency during the first five years after the operation. Subsequently, complications increasingly occurred. Ten years after the operation 18.8% of the patients had died, 11.9% had suffered a myocardial infarction, 13.4% had been subjected to a second operation and 6.4% to balloon angioplasty, while 46.4% had once more developed angina pectoris. Thirteen years after the operation 29% of the patients had remained completely free from cardiac problems.

CONCLUSION

Although arterial bypasses have been increasingly used in recent years, an indication for the use of venous transplants will continue to exist in the future, also, for certain groups of patients (those younger than 50 or older than 75 years). Our study clearly shows that with venous bypasses, also, satisfactory long-term results can be obtained.

摘要

目的

评估使用静脉搭桥进行冠状动脉手术的长期效果。

设计

前瞻性研究。

地点

荷兰尼乌韦根的圣安东尼乌斯医院。

方法

在1976年4月1日至1977年4月1日期间连续接受冠状动脉手术的446例患者中,平均11.5年(1.5个月至14.3年)后进行了完整的长期随访研究。

结果

围手术期死亡率为3%,围手术期心肌梗死发生率为6.3%,77.6%的患者实现了完全血运重建。在随机选择的100例患者中的90例中,术后平均13.5个月进行了心脏导管检查。单支移植血管的通畅率为89.8%,序贯移植血管的侧侧吻合和端端吻合的通畅率分别为90.4%和83%。术后前五年,死亡率、心肌梗死、二次手术必要性和心绞痛的发生率较低。随后,并发症越来越多地出现。术后十年,18.8%的患者死亡,11.9%的患者发生心肌梗死,13.4%的患者接受了二次手术,6.4%的患者接受了球囊血管成形术,而46.4%的患者再次出现心绞痛。术后十三年,29%的患者完全没有心脏问题。

结论

尽管近年来动脉搭桥的使用越来越多,但对于某些患者群体(年龄小于50岁或大于75岁的患者),静脉移植的应用指征在未来仍将存在。我们的研究清楚地表明,使用静脉搭桥也能获得令人满意的长期效果。

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