Chia L G, Liu L H
Neurology Section, Veterans General Hospital-Taichung, Taiwan, Republic of China.
Neuroepidemiology. 1992;11(3):113-20. doi: 10.1159/000110920.
215 Chinese Parkinson's disease (PD) patients on levodopa therapy were followed up between 1982 and 1991. The ratio of males to females was 2.4 to 1. The mean durations from onset of the illness to stages I and II of Hoehn and Yahr (mild disability) were 4.0 and 6.5 years, to stage III (moderate) 7.9 years, and to stages IV and V (severe) 9.8 and 11.8 years. The mean duration of illness for living patients was 8.6 years. The mean duration of illness before death for the 46 patients who died was 8.9 years. The mean age at death was 68 years (4.4 years less than the normal life expectancy in Taiwan). The fate of this disease showed that patients with unilateral symptoms initially had a better prognosis than those with bilateral symptoms. The symptoms at onset were unilateral in 70% of the patients, of whom 91% had a spread of symptoms to the opposite side after a mean of 3.4 years. Familial PD occurred in 2.8% of our patients. The occurrence of blood ABO groups was not significantly different between the PD patients and the general population of Taiwan. Our findings differed from those in Western series by having a predominance of males, and a relatively shorter duration of unilateral symptoms before spread to the opposite side. In addition, the duration of illness and the survival time under levodopa treatment were shorter in Taiwanese and Japanese than in Western series.
1982年至1991年期间，对215名接受左旋多巴治疗的中国帕金森病（PD）患者进行了随访。男女比例为2.4比1。从发病到Hoehn和Yahr分级的I期和II期（轻度残疾）的平均病程分别为4.0年和6.5年，到III期（中度）为7.9年，到IV期和V期（重度）分别为9.8年和11.8年。存活患者的平均病程为8.6年。46名死亡患者的平均病程为8.9年。平均死亡年龄为68岁（比台湾正常预期寿命少4.4岁）。该疾病的转归显示，最初有单侧症状的患者预后比双侧症状患者更好。70%的患者起病症状为单侧，其中91%在平均3.4年后症状扩散至对侧。2.8%的患者患有家族性帕金森病。帕金森病患者与台湾普通人群的ABO血型分布无显著差异。我们的研究结果与西方系列研究不同，表现为男性占主导，单侧症状扩散至对侧之前的持续时间相对较短。此外，台湾人和日本人在左旋多巴治疗下的病程和生存时间比西方系列研究中的要短。
