大鼠前脑和小脑的4-氨基丁酸-2-氧代戊二酸转氨酶（GABA-T）的比较研究。
Comparative study between 4-aminobutyrate-2-oxoglutarate aminotransferase (GABA-T) from rat forebrain and cerebellum.
作者信息
Arce C, Cañadas S, De Vicente M, Oset-Gasque M J, González M P
机构信息
Instituto de Bioquimica (Centro mixto C.S.I.C.-U.C.M.), Facultad de Farmacia, Ciudad Universitaria, Madrid, Spain.
出版信息
Neurochem Res. 1992 Jul;17(7):703-6. doi: 10.1007/BF00968009.
In this study differences in the biochemical properties of 4-aminobutyric acid aminotransferase (GABA-T) from forebrain and cerebellum were detected. These differences may be related to: a) the characteristics of the catalytic site, b) the substrate affinities and c) their pyridoxal-phosphate requirements which suggests that PLP could be a physiological regulator of these forms of brain GABA-T.
在本研究中，检测了来自前脑和小脑的4-氨基丁酸转氨酶（GABA-T）生化特性的差异。这些差异可能与以下因素有关：a）催化位点的特性，b）底物亲和力，以及c）它们对磷酸吡哆醛的需求，这表明磷酸吡哆醛可能是这些脑内GABA-T形式的生理调节剂。
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