极晚发型多发性硬化症

Multiple sclerosis with very late onset.

作者信息

Hooge J P, Redekop W K

机构信息

Department of Medicine, University of British Columbia, Vancouver, Canada.

出版信息

Neurology. 1992 Oct;42(10):1907-10. doi: 10.1212/wnl.42.10.1907.

DOI:10.1212/wnl.42.10.1907

PMID:1407571

Abstract

Multiple sclerosis (MS) can present clinically after age 59, but only rarely. In a large MS population (N = 2,019), 0.6% of patients had their first symptom at age 60 or older. Of this group, six had clinically definite MS, two had laboratory-supported definite MS, and four had clinically probable MS. The onset at this age was characteristically a slow deterioration of motor function. Most (10 of 12) of these very late-onset patients had a progressive course of disease from onset.

摘要

多发性硬化症（MS）可在59岁之后出现临床症状，但极为罕见。在一个大型MS患者群体（N = 2019）中，0.6%的患者在60岁及以上首次出现症状。在这组患者中，6例有临床确诊的MS，2例有实验室支持的确诊MS，4例有临床疑似MS。这个年龄段的发病特征通常是运动功能的缓慢衰退。这些极晚发病的患者中，大多数（12例中的10例）从发病起病情呈进行性发展。