中脑导水管周围灰质刺激对糖尿病大鼠产生的镇痛作用。

Periaqueductal gray matter stimulation-produced analgesia in diabetic rats.

作者信息

Kamei J, Aoki T, Kasuya Y

机构信息

Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.

出版信息

Neurosci Lett. 1992 Aug 3;142(1):13-6. doi: 10.1016/0304-3940(92)90609-b.

DOI:10.1016/0304-3940(92)90609-b

PMID:1407710

Abstract

The effect of diabetes on periaqueductal gray matter (PAG) stimulation-produced analgesia (SPA) was examined in rats. PAG SPA was assessed using the tail-pinch test. PAG stimulation produced marked analgesia in both naive and diabetic rats. Furthermore, the degree of PAG SPA did not differ between naive and diabetic rats. PAG SPA was significantly attenuated by a low dose (0.5 mg/kg, s.c.) of naloxone in naive rats, but not in diabetic rats. However, a high dose (5 mg/kg, s.c.) of naloxone significantly and equally attenuated PAG SPA in both naive and diabetic rats. On the other hand, the analgesic potency of morphine (3 mg/kg, s.c.) was significantly reduced in diabetic rats as compared with naive rats. These results suggest that PAG SPA in diabetic rats may be mediated by different opioid receptor interactions as compared with naive rats.

摘要

研究了糖尿病对大鼠中脑导水管周围灰质（PAG）刺激产生的镇痛作用（SPA）的影响。使用夹尾试验评估PAG SPA。PAG刺激在未患糖尿病和患糖尿病的大鼠中均产生明显的镇痛作用。此外，未患糖尿病和患糖尿病的大鼠之间PAG SPA的程度没有差异。低剂量（0.5mg/kg，皮下注射）的纳洛酮可使未患糖尿病大鼠的PAG SPA显著减弱，但对患糖尿病大鼠无效。然而，高剂量（5mg/kg，皮下注射）的纳洛酮可使未患糖尿病和患糖尿病的大鼠的PAG SPA均显著且同等程度地减弱。另一方面，与未患糖尿病的大鼠相比，患糖尿病大鼠中吗啡（3mg/kg，皮下注射）的镇痛效力显著降低。这些结果表明，与未患糖尿病的大鼠相比，患糖尿病大鼠的PAG SPA可能由不同的阿片受体相互作用介导。