Engelmann M, Bures J, Landgraf R
University of Leipzig, Section of Biosciences, FRG.
Neurosci Lett. 1992 Aug 3;142(1):69-72. doi: 10.1016/0304-3940(92)90622-e.
The role of vasopressin (AVP) in the septohippocampal system in spatial memory was studied in 27 male hooded rats of the Long-Evans strain. The rats were implanted with a septal microdialysis probe and assigned to 3 groups. Two days later, they were trained on 3 consecutive days (12 daily trials) to locate the hidden underwater platform in the Morris water maze (MWM) while the probes were perfused with either artificial cerebrospinal fluid (aCSF) or aCSF containing vasopressin or the V1 antagonist d(CH2)5Tyr(Me)AVP (AAVP). Another group of rats (n = 8) remained untreated. Groups receiving microdialysis of aCSF or AAVP acquired the MWM task at the same rate as untreated animals. On the other hand, place navigation learning was significantly impaired by microdialysis of AVP during all sessions. The results indicate that endogenous AVP (at least that affecting the V1 receptor subtype) is not indispensable for the acquisition of spatial memories in the MWM, whereas excessive presence of synthetic AVP interferes with spatial learning.
在27只长-伊文斯品系的雄性带帽大鼠中，研究了血管加压素（AVP）在空间记忆的隔海马系统中的作用。给大鼠植入隔区微透析探针，并分为3组。两天后，在连续3天（每天12次试验）对它们进行训练，使其在莫里斯水迷宫（MWM）中找到隐藏在水下的平台，同时向探针灌注人工脑脊液（aCSF）或含血管加压素的aCSF或V1拮抗剂d(CH2)5Tyr(Me)AVP（AAVP）。另一组大鼠（n = 8）未接受处理。接受aCSF或AAVP微透析的组与未处理的动物以相同的速率学会了MWM任务。另一方面，在所有试验阶段，AVP微透析均显著损害了位置导航学习。结果表明，内源性AVP（至少是影响V1受体亚型的AVP）对于在MWM中获取空间记忆并非必不可少，而合成AVP的过量存在会干扰空间学习。
