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本文引用的文献

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A QUANTITATIVE, ABSOLUTE METHOD FOR THE ESTIMATION OF COMPLEMENT (ALEXIN).一种定量、绝对的补体（防御素）测定方法。
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The Action of Ammonia on Complement. The Fourth Component.氨对补体的作用。第四成分。
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Isolation and description of proteins related to the human complement system.与人类补体系统相关蛋白质的分离与描述。
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Activity of CT in rabbit antisheep hemolysin.CT在兔抗羊溶血素中的活性。
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Studies on immune hemolysis: preparation of a stable and highly reactive complex of sensitized erythrocytes and the first component of complement (EAC'1): inactivation of cell-fixed C'1 by some complement reagents.免疫溶血研究：致敏红细胞与补体第一成分（EAC'1）稳定且高反应性复合物的制备：某些补体试剂对细胞固定C'1的灭活作用
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Changes produced in mouse plasma proteins by acute bacterial infections.急性细菌感染对小鼠血浆蛋白产生的变化。
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Isolation and characterization of two beta1-glycoproteins of human serum.人血清中两种β1-糖蛋白的分离与鉴定
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[Presence of beta1, B-globulin in the perchloric extracts of normal human sera].[正常人血清高氯酸提取物中β1、β-球蛋白的存在情况]
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Starch gel electrophoresis in a discontinous system of buffers.在不连续缓冲系统中的淀粉凝胶电泳。
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人补体第四成分的分离与描述

ISOLATION AND DESCRIPTION OF THE FOURTH COMPONENT OF HUMAN COMPLEMENT.

作者信息

MUELLER-EBERHARD H J, BIRO C E

出版信息

J Exp Med. 1963 Sep 1;118(3):447-66. doi: 10.1084/jem.118.3.447.

DOI:10.1084/jem.118.3.447
PMID:14078003
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2137649/
Abstract

Purification of the activity of the fourth component of human complement resulted in the isolation of a highly homogeneous serum protein. Since this protein has not been recorded previously it was called beta(1E)-globulin on the basis of its immunoelectrophoretic behavior. C'4 activity and beta(1E)-globulin were found to have highly similar, if not identical physicochemical characteristics. Moreover, beta(1E)-globulin was shown to exhibit the specific behavior of C'4 activity in that it is taken up only by cells which contain activated C'1. DFP-inactivated C'1 failed to catalyze uptake of the protein. Treatment with hydrazine which is known to destroy C'4 activity, led to changes in the physicochemical properties of beta(1E)-globulin and rendered the molecule incapable to combine with C'1-containing cells. The evidence indicates that beta(1E)-globulin represents the fourth component of human complement.

摘要

人补体第四成分活性的纯化导致分离出一种高度均一的血清蛋白。由于此前未记录过这种蛋白，根据其免疫电泳行为将其称为β(1E)-球蛋白。发现C'4活性和β(1E)-球蛋白具有高度相似（即便不是完全相同）的物理化学特性。此外，β(1E)-球蛋白表现出C'4活性的特异性行为，即它仅被含有活化C'1的细胞摄取。二异丙基氟磷酸酯（DFP）灭活的C'1无法催化该蛋白的摄取。用已知会破坏C'4活性的肼处理，导致β(1E)-球蛋白的物理化学性质发生变化，并使该分子无法与含C'1的细胞结合。证据表明β(1E)-球蛋白代表人补体的第四成分。