补体系统：历史、途径、级联反应及抑制剂
The complement system: history, pathways, cascade and inhibitors.
作者信息
Nesargikar P N, Spiller B, Chavez R
出版信息
Eur J Microbiol Immunol (Bp). 2012 Jun;2(2):103-11. doi: 10.1556/EuJMI.2.2012.2.2. Epub 2012 Jun 13.
Abstract
Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.
摘要
自19世纪被发现以来，补体系统已发展成为一个具有临床意义的实体。补体系统与多种临床病症相关，从自身免疫性疾病到移植中的缺血再灌注损伤。本文梳理了我们对补体系统认识的历史进程，并概述了其激活途径及其内在调节因子。
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本文引用的文献
1
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Immunobiology. 2012 Feb;217(2):225-34. doi: 10.1016/j.imbio.2011.07.016. Epub 2011 Jul 23.
2
Membrane attack by complement: the assembly and biology of terminal complement complexes.补体介导的膜攻击：终末补体复合物的组装与生物学。
Immunol Res. 2011 Oct;51(1):45-60. doi: 10.1007/s12026-011-8239-5.
3
Complement deficiency states and associated infections.补体缺陷状态和相关感染。
Mol Immunol. 2011 Aug;48(14):1643-55. doi: 10.1016/j.molimm.2011.05.001. Epub 2011 May 31.
4
CD46 in innate and adaptive immunity: an update.CD46 在先天免疫和适应性免疫中的作用：研究进展。
Clin Exp Immunol. 2011 Jun;164(3):301-11. doi: 10.1111/j.1365-2249.2011.04400.x. Epub 2011 Apr 13.
5
Crosstalk between complement and Toll-like receptor activation in relation to donor brain death and renal ischemia-reperfusion injury.补体与 Toll 样受体激活的串扰与供体脑死亡和肾缺血再灌注损伤有关。
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6
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Ann Med. 2012 May;44(3):205-17. doi: 10.3109/07853890.2010.535556. Epub 2011 Jan 24.
7
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Mol Med. 2011 Mar-Apr;17(3-4):317-29. doi: 10.2119/molmed.2010.00149. Epub 2010 Oct 29.
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Mol Immunol. 2010 Nov-Dec;48(1-3):9-13. doi: 10.1016/j.molimm.2010.08.016. Epub 2010 Sep 25.
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Mol Immunol. 2010 Aug;47(13):2187-97. doi: 10.1016/j.molimm.2010.05.007.
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