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补体系统：历史、途径、级联反应及抑制剂

The complement system: history, pathways, cascade and inhibitors.

作者信息

Nesargikar P N, Spiller B, Chavez R

出版信息

Eur J Microbiol Immunol (Bp). 2012 Jun;2(2):103-11. doi: 10.1556/EuJMI.2.2012.2.2. Epub 2012 Jun 13.

DOI:10.1556/EuJMI.2.2012.2.2
PMID:24672678
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3956958/
Abstract

Since its discovery in the 19th century, the complement system has developed into a clinically significant entity. The complement system has been implicated in a variety of clinical conditions, from autoimmune diseases to ischemia-reperfusion injury in transplantation. This article charts the historical progress of our understanding of the complement system and provides a synopsis on the activation pathways and its inherent regulators.

摘要

自19世纪被发现以来，补体系统已发展成为一个具有临床意义的实体。补体系统与多种临床病症相关，从自身免疫性疾病到移植中的缺血再灌注损伤。本文梳理了我们对补体系统认识的历史进程，并概述了其激活途径及其内在调节因子。

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本文引用的文献

1
The new face of anaphylatoxins in immune regulation.免疫调节中新的过敏毒素作用模式。
Immunobiology. 2012 Feb;217(2):225-34. doi: 10.1016/j.imbio.2011.07.016. Epub 2011 Jul 23.
2
Membrane attack by complement: the assembly and biology of terminal complement complexes.补体介导的膜攻击：终末补体复合物的组装与生物学。
Immunol Res. 2011 Oct;51(1):45-60. doi: 10.1007/s12026-011-8239-5.
3
Complement deficiency states and associated infections.补体缺陷状态和相关感染。
Mol Immunol. 2011 Aug;48(14):1643-55. doi: 10.1016/j.molimm.2011.05.001. Epub 2011 May 31.
4
CD46 in innate and adaptive immunity: an update.CD46 在先天免疫和适应性免疫中的作用：研究进展。
Clin Exp Immunol. 2011 Jun;164(3):301-11. doi: 10.1111/j.1365-2249.2011.04400.x. Epub 2011 Apr 13.
5
Crosstalk between complement and Toll-like receptor activation in relation to donor brain death and renal ischemia-reperfusion injury.补体与 Toll 样受体激活的串扰与供体脑死亡和肾缺血再灌注损伤有关。
Am J Transplant. 2011 Apr;11(4):660-9. doi: 10.1111/j.1600-6143.2011.03475.x.
6
Role of complement and perspectives for intervention in ischemia-reperfusion damage.补体的作用及在缺血再灌注损伤干预中的前景。
Ann Med. 2012 May;44(3):205-17. doi: 10.3109/07853890.2010.535556. Epub 2011 Jan 24.
7
New insights of an old defense system: structure, function, and clinical relevance of the complement system.新视角下的古老防御系统：补体系统的结构、功能与临床相关性。
Mol Med. 2011 Mar-Apr;17(3-4):317-29. doi: 10.2119/molmed.2010.00149. Epub 2010 Oct 29.
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Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity.收集素 11（CL-11，CL-K1）是一种与 MASP-1/3 相关的血浆收集素，具有微生物结合活性。
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Transcriptional control of genes for soluble complement cascade regulatory proteins.可溶性补体级联调节蛋白基因的转录控制。
Mol Immunol. 2010 Nov-Dec;48(1-3):9-13. doi: 10.1016/j.molimm.2010.08.016. Epub 2010 Sep 25.
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Complement control protein factor H: the good, the bad, and the inadequate.补体控制蛋白因子 H：好的、坏的和不足的。
Mol Immunol. 2010 Aug;47(13):2187-97. doi: 10.1016/j.molimm.2010.05.007.