Chen C, Roby P V, Weiss N S, Wilson J A, Benedetti T J, Tait J F
Department of Laboratory Medicine, University of Washington, Seattle.
Obstet Gynecol. 1992 Oct;80(4):688-92.
We identified 389 women who had FP analysis performed at the University of Washington Medical Center from February 1986 to October 1988 and who delivered within 3 days of amniocentesis. We reviewed the medical records of these women and their infants to extract information for our study.
For FP values of 0.26 or greater, the sensitivity and specificity for prediction of RDS were 90.2 and 84.6%, respectively, compared with 100 and 82.0% in the previous study. For FP values of 0.29 or greater, the sensitivity and specificity were 62.8 and 94.2%, respectively (80.8 and 96.2% in the previous study). Among diabetics, an FP result below 0.26 was associated with the same low risk of RDS as among non-diabetics. Among the patients with FP between 0.26-0.289, the addition of L/S did not provide a clinically useful improvement in the prediction of fetal lung maturity.
The NBD-PC FP assay can be used as the sole test of fetal lung maturity in most clinical circumstances.
1）使用一组独立数据检验荧光偏振（FP）检测方法，该数据集包含的呼吸窘迫综合征（RDS）病例数比之前的研究更多；2）确定相同的参考范围是否适用于糖尿病女性所生婴儿；3）评估添加卵磷脂 - 鞘磷脂比值（L/S）是否会显著改善FP值处于中间范围（0.26 - 0.289）的女性中RDS的预测情况。
我们确定了1986年2月至1988年10月在华盛顿大学医学中心接受FP分析且在羊膜穿刺术3天内分娩的389名女性。我们查阅了这些女性及其婴儿的病历以提取研究所需信息。
对于FP值为0.26或更高的情况，预测RDS的敏感性和特异性分别为90.2%和84.6%，而之前的研究中分别为100%和82.0%。对于FP值为0.29或更高的情况，敏感性和特异性分别为62.8%和94.2%（之前的研究中分别为80.8%和96.2%）。在糖尿病患者中，FP结果低于0.26与非糖尿病患者中RDS的低风险相同。在FP值介于0.26 - 0.289之间的患者中，添加L/S在预测胎儿肺成熟度方面未提供临床上有用的改善。
在大多数临床情况下，NBD - PC FP检测可作为胎儿肺成熟度的唯一检测方法。
