LUCKE H H, HODGE K E, PATT N L
Can Med Assoc J. 1963 Nov 30;89(22):1111-4.
Tannic acid contained in the barium enema was found to have been the sole known potential hepatotoxin in four of the five cases of fulminating fatal liver failure that occurred in a 213-bed hospital over a period of 27 months. In the other case halothane anesthesia had also been administered. Autopsies (performed on four of the cases) did not suggest viral hepatitis but showed substantially indentical hepatic changes, not unlike those reported in the past following tannic acid exposure. Proof is not claimed that tannic acid was the cause of these deaths, but further investigation regarding the safety of its administration in barium enemas is advocated.
在一家拥有213张床位的医院，27个月内发生了5例暴发性致死性肝功能衰竭病例，其中4例发现钡灌肠剂中含有的鞣酸是唯一已知的潜在肝毒素。另一例还接受了氟烷麻醉。（4例进行了尸检）尸检结果未提示病毒性肝炎，但显示出基本相同的肝脏变化，与过去报道的鞣酸暴露后的变化并无不同。虽然不能断言鞣酸就是这些死亡病例的病因，但主张对其在钡灌肠剂中的使用安全性进行进一步调查。
