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Toxoplasma gondii: characterization of a mutant resistant to 5-fluorodeoxyuridine.

作者信息

Pfefferkorn E R, Pfefferkorn L C

出版信息

Exp Parasitol. 1977 Jun;42(1):44-55. doi: 10.1016/0014-4894(77)90060-1.

DOI:10.1016/0014-4894(77)90060-1
PMID:140809
Abstract
摘要

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Selection Implicates ROP1 as a Resistance Gene for an Experimental Therapeutic Benzoquinone Acyl Hydrazone in Toxoplasma gondii.
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Forward genetic screening identifies a small molecule that blocks Toxoplasma gondii growth by inhibiting both host- and parasite-encoded kinases.正向遗传学筛选鉴定出一种小分子，该小分子通过抑制宿主和寄生虫编码的激酶来阻断弓形虫的生长。
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