Tsuchiya M, Yoshida T, Asakura H, Hibi T, Ono A
Digestion. 1977;15(4):286-94. doi: 10.1159/000198014.
The HLA antigens in 44 cases of ulcerative colitis and 271 control individuals in Japan were studied. The NIH tissue typing method was used according to the new leukocyte nomenclature adapted by the WHO Committee. In normal Japanese populations, the HLA antigens, which were of high frequency, were HLA A2(37.3%), A9(60.9%) and B5 (40.6%). On the contrary, the significantly high frequency of HLA B5 was demonstrated in ulcerative colitis, compared with that in control. Moreover, HLA B5 in cases with ulcerative colitis excluding those with proctitis only, was found with higher frequency than that in total cases. Although the most frequent haplotype was HLA A9-B5 in control, so frequent haplotype was not found in ulcerative colitis. A family study revealed no significant diathesis on the hapolytpe of HLA in ulcerative colitis. The relationship between MLC locus and ulcerative colitis was not yet clarified from the study of one family whose two members suffered from ulcerative colitis.
对日本44例溃疡性结肠炎患者和271名对照个体的HLA抗原进行了研究。根据世界卫生组织委员会采用的新白细胞命名法，使用美国国立卫生研究院组织分型方法。在正常日本人群中，高频出现的HLA抗原为HLA A2（37.3%）、A9（60.9%）和B5（40.6%）。相反，与对照组相比，溃疡性结肠炎患者中HLA B5的频率显著升高。此外，仅排除直肠炎患者的溃疡性结肠炎病例中HLA B5的频率高于全部病例。虽然对照组中最常见的单倍型是HLA A9 - B5，但在溃疡性结肠炎患者中未发现如此常见的单倍型。一项家系研究显示，溃疡性结肠炎患者的HLA单倍型不存在显著的易感性。对一个有两名成员患溃疡性结肠炎的家系进行研究，尚未明确MLC位点与溃疡性结肠炎之间的关系。
