Caruso C, Palmeri P, Oliva L, Orlando A, Cottone M
Tissue Antigens. 1985 Jan;25(1):47-9. doi: 10.1111/j.1399-0039.1985.tb00411.x.
HLA antigens were investigated in 41 Sicilian patients with ulcerative colitis and in 151 healthy controls. Frequencies of HLA-B5 and DR2 were increased in the group of patients with ulcerative colitis whereas the DR3 antigen frequency was decreased. However the corrected p values were not significant. Thus, present results indicate that in ulcerative colitis HLA linked genetic factors play a marginal role, if any.
对41名患有溃疡性结肠炎的西西里患者和151名健康对照者进行了HLA抗原研究。溃疡性结肠炎患者组中HLA - B5和DR2的频率增加，而DR3抗原频率降低。然而，校正后的p值并不显著。因此，目前的结果表明，在溃疡性结肠炎中，HLA相关的遗传因素即使有作用，也只起很小的作用。
