Lishmanov Iu B, Maslov L N, Khaliulin I G, Barabash N A, Evtushenko S Ia, Miliaeva M V, Meerson F Z
Patol Fiziol Eksp Ter. 1992 Mar-Apr(2):25-7.
It was found that adaptation of rats to cold and physical exercise prevented ventricular fibrillation caused by occlusion of the left anterior coronary artery. Adaptation to cold or only to physical exercise did not prevent ventricular arrhythmias. A significant increase of the beta-endorphin content in the hypophysis and hypothalamus was demonstrated in all adapted rats. An increased content of meth-enkephalin (ME) in the myocardium was found only in rats adapted to cold and physical exercise. It is suggested that increase of the myocardial ME content is of essential significance in the antiarrhythmic action of adaptation.
研究发现，大鼠适应寒冷和进行体育锻炼可预防左冠状动脉前降支闭塞所致的心室颤动。单纯适应寒冷或仅进行体育锻炼并不能预防心律失常。所有适应的大鼠垂体和下丘脑的β-内啡肽含量均显著增加。仅在适应寒冷和体育锻炼的大鼠心肌中发现甲硫氨酸脑啡肽（ME）含量增加。提示心肌ME含量增加在适应的抗心律失常作用中具有重要意义。
