Maslov L N, Lishmanov Iu B
Vopr Med Khim. 1992 Mar-Apr;38(2):21-3.
After occlusion of the anterior descending coronary artery content of opioid peptides was increased 2-3-fold in blood plasma of all the rats with and without ventricular fibrillation. Content of Leu-enkephalin was decreased in ischemic and non-ischemic regions of myocardium under conditions of ventricular fibrillation. At the same time, concentration of Met-enkephalin in myocardium was increased in the acute ischemia independently on the effect of fibrillation. Synthetic enzyme-resistant derivative of Leu-enkephalin, administered before acute myocardial ischemia, prevented a decrease in the ventricular fibrillation threshold caused by the occlusion. Alteration of the Leu-enkephalin content in heart tissue appears to be importance in pathogenesis of ventricular fibrillation developed after acute myocardial ischemia.
在冠状动脉前降支闭塞后，所有大鼠（无论有无心室颤动）血浆中的阿片肽含量增加了2 - 3倍。在心室颤动的情况下，心肌缺血和非缺血区域的亮脑啡肽含量降低。与此同时，急性缺血时心肌中甲硫脑啡肽的浓度增加，与颤动的影响无关。在急性心肌缺血前给予亮脑啡肽的合成酶抗性衍生物，可防止闭塞引起的心室颤动阈值降低。心脏组织中亮脑啡肽含量的改变似乎在急性心肌缺血后发生的心室颤动发病机制中起重要作用。
