[Dose-dependent effect of diltiazem on some lipid metabolic parameters in hemorrhagic shock in cats].

The possibility of modulating the phospholipid composition in the plasma membranes of hepatocytes and adipocytes by the calcium channel blocker diltiazem was studied on a model of hemorrhagic shock. Diltiazem injection facilitated normalization of phosphatidylinositol metabolism in the hepatocyte plasma membranes. Injection of a high dose of diltiazem was attended by a rise of the phosphatidylethanolamine level. Only low doses of diltiazem caused a normalizing effect on the phospholipid composition of adipocyte plasma membranes. A low dose of diltiazem caused a reduction in the content of very low density lipoproteins in venous blood, while a high dose reduced the content of low density lipoproteins.