Leskova G F, Udobichenko V I, Kalinina M V
Patol Fiziol Eksp Ter. 1992 Mar-Apr(2):39-41.
The possibility of modulating the phospholipid composition in the plasma membranes of hepatocytes and adipocytes by the calcium channel blocker diltiazem was studied on a model of hemorrhagic shock. Diltiazem injection facilitated normalization of phosphatidylinositol metabolism in the hepatocyte plasma membranes. Injection of a high dose of diltiazem was attended by a rise of the phosphatidylethanolamine level. Only low doses of diltiazem caused a normalizing effect on the phospholipid composition of adipocyte plasma membranes. A low dose of diltiazem caused a reduction in the content of very low density lipoproteins in venous blood, while a high dose reduced the content of low density lipoproteins.
在失血性休克模型上研究了钙通道阻滞剂地尔硫卓调节肝细胞和脂肪细胞质膜磷脂组成的可能性。注射地尔硫卓有助于肝细胞质膜中磷脂酰肌醇代谢正常化。注射高剂量地尔硫卓会伴随磷脂酰乙醇胺水平升高。只有低剂量地尔硫卓对脂肪细胞质膜的磷脂组成产生正常化作用。低剂量地尔硫卓使静脉血中极低密度脂蛋白含量降低，而高剂量则降低低密度脂蛋白含量。
