山莨菪碱对失血性休克肝脏脂蛋白代谢及肝细胞质膜磷脂的影响

[The effect of anisodamine on lipoprotein metabolism in the liver and the plasma membrane phospholipids of the hepatocytes in hemorrhagic shock].

作者信息

Leskova G F, Su L B, Udovichenko V I

出版信息

Patol Fiziol Eksp Ter. 1990 Jan-Feb(1):15-7.

Abstract

The effect of anisodamine on lipoprotein metabolism in the liver and hepatocyte membrane phospholipids was studied on a model of hemorrhagic shock. Preliminary injection of anisodamine raised the content of very low-density lipoproteins in blood of the central vessels and intensified the breakdown of low-density lipoproteins in the liver. The main changes in the phospholipid composition of the hepatocyte plasma membranes in hemorrhagic shock are associated with phosphatidylcholine and phosphatidylinositol. Decrease of the phosphatidylcholine content and increase of the phosphatidylinositol level were encountered. Anisodamine reduces the level of phosphatidylinositol in the hepatocyte plasma membranes and brings it close to normal.

摘要

在失血性休克模型上研究了山莨菪碱对肝脏脂蛋白代谢及肝细胞膜磷脂的影响。预先注射山莨菪碱可提高中心血管血液中极低密度脂蛋白的含量，并增强肝脏中低密度脂蛋白的分解。失血性休克时肝细胞质膜磷脂组成的主要变化与磷脂酰胆碱和磷脂酰肌醇有关。出现了磷脂酰胆碱含量降低和磷脂酰肌醇水平升高的情况。山莨菪碱可降低肝细胞质膜中磷脂酰肌醇的水平并使其接近正常。

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