Khosla S N, Kumar D, Singh V
Medical College and Hospital, Rohtak, Haryana, India.
Postgrad Med J. 1992 Apr;68(798):268-71. doi: 10.1136/pgmj.68.798.268.
Lymphocyte adenosine deaminase (L-ADA) activity, a measure of lymphocyte activity, was estimated in 10 healthy controls and 30 patients with typhoid fever (20 uncomplicated and 10 complicated) at the time of admission, at onset of complications and weekly until recovery. Mean L-ADA activity in healthy controls was 20.49 +/- 3.62 mU/10(6) cells. In uncomplicated patients L-ADA activity was 36.33 +/- 5.09 mU/10(6) cells at time of admission, which is significantly raised as compared to controls. It remained high at the height of the fever and at defervescence. In complicated patients L-ADA activity was significantly low at admission (15.33 +/- 2.35 mU/10(6) cells) and fell further with development of complications (7.86 +/- 4.07 mU/10(6) cells). At defervescence L-ADA activity increased significantly above the control activity (31.24 +/- 5.37). Serial L-ADA activity can be of prognostic significance. A cut-off value of 24 mU/10(6) cells is suggested to predict prognosis and severity of disease. Activity below this indicates a probability of a severe, prolonged course and may help in instituting early and energetic treatment.
淋巴细胞腺苷脱氨酶（L-ADA）活性是淋巴细胞活性的一种衡量指标，对10名健康对照者以及30名伤寒患者（20名非复杂性患者和10名复杂性患者）在入院时、出现并发症时以及每周直至康复期间进行了评估。健康对照者的平均L-ADA活性为20.49±3.62 mU/10⁶细胞。非复杂性患者入院时的L-ADA活性为36.33±5.09 mU/10⁶细胞，与对照者相比显著升高。在发热高峰期和退热期其活性仍保持较高水平。复杂性患者入院时的L-ADA活性显著降低（15.33±2.35 mU/10⁶细胞），并随着并发症的发展进一步下降（7.86±4.07 mU/10⁶细胞）。在退热时，L-ADA活性显著高于对照者活性（31.24±5.37）。连续监测L-ADA活性可能具有预后意义。建议以24 mU/10⁶细胞作为临界值来预测疾病的预后和严重程度。低于此活性表明疾病可能病程严重且迁延，这可能有助于开展早期积极治疗。
