腺苷脱氨酶在前体T细胞成熟早期阶段的作用。
Role of adenosine deaminase in the early stages of precursor T cell maturation.
作者信息
Shore A, Dosch H M, Gelfand E W
出版信息
Clin Exp Immunol. 1981 Apr;44(1):152-5.
Abstract
The role of adenosine deaminase in the initial stages of precursor T cell differentiation was examined in patients with adenosine deaminase deficiency. Incubation of precursor T cells from adenosine deaminase-deficient patients directly in contact with thymic epithelial monolayers induced receptors for sheep erythrocytes (E rosettes). Pretreatment of these monolayers with erythro-9-(2-hydroxy-3-nonyl) adenine, an inhibitor of adenosine deaminase, prevented differentiation only of adenosine deaminase-deficient T cell precursors, and this could be restored by providing adenosine deaminase following the incubation with thymic epithelial cells. These studies indicate a role for adenosine deaminase in the earliest stages of T cell differentiation.
摘要
在腺苷脱氨酶缺乏症患者中，研究了腺苷脱氨酶在前体T细胞分化初始阶段的作用。将腺苷脱氨酶缺乏症患者的前体T细胞直接与胸腺上皮单层细胞共培养，可诱导出绵羊红细胞受体（E花环）。用腺苷脱氨酶抑制剂erythro-9-(2-羟基-3-壬基)腺嘌呤预处理这些单层细胞，仅能阻止腺苷脱氨酶缺乏的T细胞前体的分化，而在与胸腺上皮细胞共培养后提供腺苷脱氨酶，这种分化可得以恢复。这些研究表明腺苷脱氨酶在T细胞分化的最早阶段发挥作用。
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