Mirhadi S A, Singh S, Gupta P P
Department of Biochemistry, Punjab Agricultural University, Ludhiana.
Indian Heart J. 1990 Mar-Apr;42(2):99-104.
Feeding of cholesterol-rich diet to male rabbits increases collagen biosynthesis and accumulation in aorta, liver, kidney, heart and lungs. However, when garlic supplemented atherogenic diet was fed to the animals, the above effects were partially suppressed particularly in the aorta. Cholesterol content of plasma, aorta and liver, which was tremendously increased on atherogenic diet, was suppressed when garlic was included in this diet. It is suggested that garlic possibly reduced the accumulation of collagen through more mobilisation of lipids and/or decreased biosynthesis and maturation of collagen. Histopathological studies also supported this view.
给雄性兔子喂食富含胆固醇的饮食会增加主动脉、肝脏、肾脏、心脏和肺部的胶原蛋白生物合成和积累。然而，当给动物喂食添加了大蒜的致动脉粥样化饮食时，上述影响会部分受到抑制，尤其是在主动脉中。致动脉粥样化饮食使血浆、主动脉和肝脏中的胆固醇含量大幅增加，而当大蒜包含在这种饮食中时，胆固醇含量会受到抑制。有人认为，大蒜可能通过更多地调动脂质和/或减少胶原蛋白的生物合成和成熟来减少胶原蛋白的积累。组织病理学研究也支持这一观点。
