脱氢表雄酮可增强乙醇和戊巴比妥的催眠及体温降低作用。

Dehydroepiandrosterone enhances the hypnotic and hypothermic effects of ethanol and pentobarbital.

作者信息

Melchior C L, Ritzmann R F

机构信息

Brentwood Division Research, West Los Angeles Veterans Administration, CA 90073.

出版信息

Pharmacol Biochem Behav. 1992 Sep;43(1):223-7. doi: 10.1016/0091-3057(92)90661-x.

DOI:10.1016/0091-3057(92)90661-x

PMID:1409808

Abstract

Recent reports have indicated that the neurosteroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) interact with the GABAA receptor complex. Because many of the behavioral effects of ethanol and pentobarbital are due to activity at this complex, DHEA and DHEAS were tested for their ability to interact with the hypnotic and hypothermic effects of ethanol and pentobarbital. DHEA, but not DHEAS, causes a dose-dependent increase in the sleep time induced by either ethanol or pentobarbital. At 20 mg/kg, DHEA and DHEAS themselves cause a fall in body temperature. DHEA enhances the hypothermic effect of both ethanol and pentobarbital. DHEAS enhances the hypothermic effect of ethanol, but with pentobarbital it only delays the return of body temperature to baseline levels. Neither DHEA nor DHEAS affects the metabolism of ethanol.

摘要

最近的报告表明，神经甾体脱氢表雄酮（DHEA）及其硫酸盐（DHEAS）与GABAA受体复合物相互作用。由于乙醇和戊巴比妥的许多行为效应是由于该复合物的活性所致，因此测试了DHEA和DHEAS与乙醇和戊巴比妥的催眠和体温过低效应相互作用的能力。DHEA而非DHEAS会导致乙醇或戊巴比妥诱导的睡眠时间呈剂量依赖性增加。在20mg/kg时，DHEA和DHEAS本身会导致体温下降。DHEA增强乙醇和戊巴比妥的体温过低效应。DHEAS增强乙醇的体温过低效应，但对于戊巴比妥，它只会延迟体温恢复到基线水平。DHEA和DHEAS均不影响乙醇的代谢。