利用CXB重组近交系小鼠检测行为中的数量性状基因座。

The use of CXB recombinant inbred mice to detect quantitative trait loci in behavior.

作者信息

Neiderhiser J M, Plomin R, McClearn G E

机构信息

Center for Developmental and Health Genetics, Pennsylvania State University, University Park 16802.

出版信息

Physiol Behav. 1992 Sep;52(3):429-39. doi: 10.1016/0031-9384(92)90328-y.

DOI:10.1016/0031-9384(92)90328-y

PMID:1409902

Abstract

Although recombinant inbred (RI) series of mice have been developed to identify and map single-gene characteristics, they can also be used to identify quantitative trait loci (QTL) that account for small amounts of variance in quantitative traits such as behavior. We applied an RI QTL approach to the analysis of published behavioral data from seven studies that used the CXB RI series of mice. Nearly all of the behaviors showed strain distribution patterns indicative of multiple-gene rather than single-gene influence. Although the CXB series is limited to seven RI strains, RI QTL association analysis suggests QTL candidate markers for several behaviors, including avoidance and exploration.

摘要

尽管已经培育出重组近交（RI）系小鼠来识别和定位单基因特征，但它们也可用于识别数量性状位点（QTL），这些位点可解释行为等数量性状中的少量变异。我们应用RI QTL方法分析了来自七项研究的已发表行为数据，这些研究使用了CXB RI系小鼠。几乎所有行为都显示出表明多基因而非单基因影响的品系分布模式。尽管CXB系仅限于七个RI品系，但RI QTL关联分析为包括回避和探索在内的几种行为提出了QTL候选标记。