Ishikawa M, Hara C, Ohdo S, Ogawa N
Department of Pharmacology, Ehime University School of Medicine, Japan.
Physiol Behav. 1992 Sep;52(3):475-80. doi: 10.1016/0031-9384(92)90333-w.
The purpose of present study was to investigate the physiological characteristics of sociopsychological stress induced by the communication box method. In this method, the nonfoot shocked rats were used as the psychologically stressed experimental group. In acute stress experiments, nonfoot shocked rats were exposed to emotional responses from foot shocked rats for 6 h in the light (0900-1500) or in the dark phase (2100-0300). In the light phase, the induced increase in plasma corticosterone levels of nonfoot shocked and foot shocked rats returned to corresponding control levels 6 h following the initiation of stress session, whereas those in the dark phase were significantly higher. Although there were some differences in corticosterone responses between both phases, the acute effect of sociopsychological stress was unclear. Chronic stress experiment with daily exposure for 1 h to sociopsychological stress caused the plasma corticosterone levels of nonfoot shocked rats to increase significantly not only in the postexposure level (just after stress exposure) but also in the preexposure level (before stress exposure) when naive rats were used daily as foot shocked animals. These results suggest that the repeated exposure of sociopsychological stress can induce physiological changes, and stressful situation can be established with only emotional responses from foot shocked rats.
本研究的目的是探究通过交流箱法诱导的社会心理应激的生理特征。在该方法中，未遭受足部电击的大鼠被用作心理应激实验组。在急性应激实验中，未遭受足部电击的大鼠在光照期（09:00 - 15:00）或黑暗期（21:00 - 03:00）暴露于遭受足部电击大鼠的情绪反应中6小时。在光照期，应激期开始6小时后，未遭受足部电击和遭受足部电击大鼠血浆皮质酮水平的诱导性升高恢复到相应的对照水平，而在黑暗期则显著更高。尽管两个阶段的皮质酮反应存在一些差异，但社会心理应激的急性效应尚不清楚。当每天使用未接触过实验的大鼠作为遭受足部电击的动物时，每天暴露于社会心理应激1小时的慢性应激实验导致未遭受足部电击大鼠的血浆皮质酮水平不仅在暴露后水平（应激暴露后立即）显著升高，而且在暴露前水平（应激暴露前）也显著升高。这些结果表明，反复暴露于社会心理应激可诱导生理变化，并且仅通过遭受足部电击大鼠的情绪反应就能建立应激状态。
