Barlow S M, Knight A F, Sullivan F M
J Pharm Pharmacol. 1979 Jan;31(1):23-6. doi: 10.1111/j.2042-7158.1979.tb13415.x.
The effect of daily, oral administration of diazepam on plasma corticosterone responses to stressors of varying intensity was investigated. In rats exposed to the mild stress of noise, diazepam, 10 mg kg-1 but not 1.0 or 0.1 mg kg-1, reduced plasma corticosterone concentrations by 30% in comparison with controls. However, in rats exposed to the more severe stressors, foot-shock or immobilization, none of these doses of diazepam reduced plasma corticosterone responses. In unstressed rats, diazepam 10 mg kg-1 raised plasma corticosterone concentrations. It is suggested that plasma corticosterone concentrations are not a reliable indicator of the tranquillizing effect of diazepam during stress.
研究了每日口服地西泮对不同强度应激源引起的血浆皮质酮反应的影响。在暴露于轻度噪声应激的大鼠中，10mg/kg的地西泮可使血浆皮质酮浓度比对照组降低30%，而1.0mg/kg和0.1mg/kg则无此作用。然而，在暴露于更严重应激源（足部电击或固定）的大鼠中，这些剂量的地西泮均未降低血浆皮质酮反应。在未应激的大鼠中，10mg/kg的地西泮可提高血浆皮质酮浓度。这表明，在应激期间，血浆皮质酮浓度并非地西泮镇静作用的可靠指标。
