VEERARAGHAVAN N, SUBRAHMANYAN T P
Bull World Health Organ. 1963;29(4):511-4.
Studies undertaken to determine the resistance of guinea-pigs which have survived a moderate challenge as a result of treatment with serum and vaccine to subsequent severe challenges with homologous and heterologous strains of rabies street virus have shown that, even with large groups of animals, treatment with serum and vaccine saved nearly 70% of the animals against challenges of about 100 LD(50). The animals which survived such treatment and challenge continued to have a considerable degree of immunity to rechallenge even 15 months after the first treatment. There was no advantage in giving two booster doses of vaccine during this period. The immune status of rechallenged guinea-pigs seemed to depend primarily on the original treatment rather than on the strain of virus used for the first challenge. Guinea-pigs which survived an earlier challenge as a result of treatment fared better against the later challenge than fresh groups of treated but not challenged animals given the same challenge.
为了确定因血清和疫苗治疗而在中度攻击中存活下来的豚鼠对随后用狂犬病街病毒同源和异源毒株进行的严重攻击的抵抗力，所开展的研究表明，即使是对大量动物而言，血清和疫苗治疗也能使近70%的动物在面对约100个半数致死量（LD50）的攻击时存活下来。在首次治疗后长达15个月的时间里，经此类治疗并存活下来的动物在面对再次攻击时仍具有相当程度的免疫力。在此期间给予两剂加强疫苗并无益处。再次接受攻击的豚鼠的免疫状态似乎主要取决于最初的治疗，而非用于首次攻击的病毒毒株。因治疗而在早期攻击中存活下来的豚鼠，在面对后期攻击时，比接受相同攻击但未经前期攻击的新治疗组豚鼠表现更好。
