Mihăilescu R, Pop C, Mihancea N, Voiculescu R, Merca V, Alexandrescu N, Iancu V, Georgescu C
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1977 Jan-Mar;22(1):35-41.
A study was carried out on the humoral response and vaccinal reaction after repeated administration of the smallpox vaccine (1 to 3 times), at ten days interval, to 97 subjects with a past history of repeated vaccination failures. Revaccination ended in 52.6% failures. After revaccination the antibody titer increased in 97.8% of the cases of successful vaccination and in 43.5% of the negative cases. In 29.5% of the latter cases a decrease in the antibody titer by 1--3 binary dilutions was found. The results suggest that the repeated application at short intervals of an antigenic stimulus perturbs the immune response.
对97名有多次接种失败病史的受试者每隔10天重复接种天花疫苗（1至3次），进行了一项关于体液反应和疫苗反应的研究。再次接种的失败率为52.6%。再次接种后，成功接种的病例中有97.8%抗体滴度升高，阴性病例中有43.5%抗体滴度升高。在后一组病例中，29.5%的病例抗体滴度下降了1至3个二倍稀释度。结果表明，短时间间隔内重复给予抗原刺激会扰乱免疫反应。
