Nevins J R
Howard Hughes Medical Institute, Section of Genetics, Duke University Medical Center, Durham, NC 27710.
Science. 1992 Oct 16;258(5081):424-9. doi: 10.1126/science.1411535.
The cellular transcription factor E2F, previously identified as a component of early adenovirus transcription, has now been shown to be important in cell proliferation control. E2F appears to be a functional target for the action of the tumor suppressor protein Rb that is encoded by the retinoblastoma susceptibility gene. The disruption of this E2F-Rb interaction, as well as a complex involving E2F in association with the cell cycle-regulated cyclin A-cdk2 kinase complex, may be a common mechanism of action for the oncoproteins encoded by the DNA tumor viruses.
细胞转录因子E2F，先前被鉴定为早期腺病毒转录的一个组成部分，现在已被证明在细胞增殖控制中起重要作用。E2F似乎是由视网膜母细胞瘤易感基因编码的肿瘤抑制蛋白Rb作用的功能靶点。这种E2F-Rb相互作用的破坏，以及涉及E2F与细胞周期调节的细胞周期蛋白A-cdk2激酶复合物的复合物，可能是DNA肿瘤病毒编码的癌蛋白的常见作用机制。
