Martin R A, Jones K L, Mendoza A, Barr M, Benirschke K
Department of Pediatrics, University of California Medical Center, San Diego 92103.
Teratology. 1992 Oct;46(4):317-21. doi: 10.1002/tera.1420460402.
The kidneys of nine fetuses whose mothers were chronically hypertensive were examined microscopically. Three of these mothers used antihypertensive agents throughout pregnancy including one who used an angiotensin-converting enzyme (ACE) inhibitor. The tubular defects found in these kidneys were compared to the kidneys of 20 normal controls, 13 fetuses with various multiple malformation syndromes and six cases of the twin to twin transfusion syndrome. Evidence from these cases as well as the literature suggest that the primary mechanism by which ACE inhibitors affect development of the fetal kidney is through decreased renal blood flow.
对9名母亲患有慢性高血压的胎儿的肾脏进行了显微镜检查。这些母亲中有3人在整个孕期都使用了抗高血压药物，其中1人使用了血管紧张素转换酶（ACE）抑制剂。将这些肾脏中发现的肾小管缺陷与20名正常对照胎儿、13名患有各种多发畸形综合征的胎儿以及6例双胎输血综合征病例的肾脏进行了比较。这些病例以及文献中的证据表明，ACE抑制剂影响胎儿肾脏发育的主要机制是肾血流量减少。
