Marckmann P, Lerche C, Nørtoft L L
Ankerhus Seminarium, Sorø.
Ugeskr Laeger. 1992 Aug 17;154(34):2288-92.
The effect of a daily dietary supplement of 6 g fish oil (3.4 g eicosapentaenoic and docosahexaenoic acid) on body weight, blood pressure, bleeding time and blood lipids was assessed in an open trial. The fish oil was taken for four weeks by nine 30-55 year-old individuals. An age- and sex-matched control group took equivalent amounts of safflower oil, which has an overall fatty acid composition similar to the tested fish oil. The fish oil supplement caused significant changes in body weight (median: +0.9 kg), systolic blood pressure (-10 mmHg), diastolic blood pressure (-5 mmHg), and high density lipoprotein (HDL) cholesterol concentration (+0.21 mmol/l), whereas serum triglycerides decreased insignificantly (-0.25 mmol/l). Low density lipoprotein (LDL) concentration were not affected. We observed no changes in the control group. In the discussion, it is underlined that fish oil supplementation may affect some risk markers of ischemic heart disease favourably. However, other important risk markers, including LDL cholesterol, are unaffected or unfavourably affected by fish oils. A more uni-directional reduction in risk can be attained by a change in dietary habits, which should be preferable to a fish oil supplement in the general population. Individuals who show critically low HDL/total cholesterol ratios, who are hypertriglyceridemic, or are mildly hypertensive may, however, benefit from a fish oil supplement of the amount tested here.
在一项开放性试验中，评估了每日补充6克鱼油（3.4克二十碳五烯酸和二十二碳六烯酸）对体重、血压、出血时间和血脂的影响。9名30至55岁的个体服用鱼油四周。一个年龄和性别匹配的对照组服用等量的红花油，其总体脂肪酸组成与受试鱼油相似。补充鱼油导致体重（中位数：增加0.9千克）、收缩压（降低10毫米汞柱）、舒张压（降低5毫米汞柱）和高密度脂蛋白（HDL）胆固醇浓度（增加0.21毫摩尔/升）出现显著变化，而血清甘油三酯略有下降（降低0.25毫摩尔/升）。低密度脂蛋白（LDL）浓度未受影响。我们在对照组中未观察到变化。在讨论中强调，补充鱼油可能对缺血性心脏病的一些风险指标产生有利影响。然而，其他重要的风险指标，包括LDL胆固醇，不受鱼油影响或受到不利影响。通过改变饮食习惯可以实现更具单向性的风险降低，在一般人群中，这应优于补充鱼油。然而，HDL/总胆固醇比值极低、高甘油三酯血症或轻度高血压的个体可能会从此处测试剂量的鱼油补充剂中受益。
