Sacks F M, Hebert P, Appel L J, Borhani N O, Applegate W B, Cohen J D, Cutler J A, Kirchner K A, Kuller L H, Roth K J
Channing Laboratory, Boston, MA.
J Hypertens. 1994 Feb;12(2):209-13.
To study the effects of moderate doses of fish oil on blood pressure and high-density lipoprotein (HDL)-cholesterol.
The participants were 350 normotensive men and women aged 30-54 years who were enrolled from seven academic medical centers in phase I of the Trials of Hypertension Prevention. They were randomly assigned to receive placebo or 6 g purified fish oil once a day, which supplied 3 g n-3 polyunsaturated fatty acids for 6 months.
Baseline blood pressure was (mean +/- SD) 123 +/- 9/81 +/- 5 mmHg. The mean differences in the blood pressure changes between the fish oil and placebo groups were not statistically significant. There was no tendency for fish oil to reduce blood pressure more in subjects with baseline blood pressure in the upper versus the lower quartile (132/87 versus 114/75 mmHg), low habitual fish consumption (0.4 versus 2.9 times a week) or low baseline plasma levels of n-3 fatty acids. Fish oil increased HDL2-cholesterol significantly compared with the placebo group. Subgroup analysis showed this effect to be significant in the women but not in the men. Increases in serum phospholipid n-3 fatty acids were significantly correlated with increases in HDL2-cholesterol and decreases in systolic blood pressure.
Moderate amounts of fish oil (6 g/day) are unlikely to lower blood pressure in normotensive persons, but may increase HDL2-cholesterol, particularly in women.
研究中等剂量鱼油对血压和高密度脂蛋白（HDL）胆固醇的影响。
参与者为350名年龄在30 - 54岁的血压正常的男性和女性，他们来自高血压预防试验第一阶段的七个学术医学中心。将他们随机分配，分别接受安慰剂或每天一次6克纯化鱼油，持续6个月，其中6克纯化鱼油可提供3克n - 3多不饱和脂肪酸。
基线血压为（均值±标准差）123±9/81±5 mmHg。鱼油组和安慰剂组血压变化的平均差异无统计学意义。对于基线血压处于上四分位数（132/87 mmHg）与下四分位数（114/75 mmHg）的受试者、习惯性鱼类摄入量低（每周0.4次与2.9次）或基线血浆n - 3脂肪酸水平低的受试者，鱼油均没有更明显的降血压趋势。与安慰剂组相比，鱼油显著增加了HDL2胆固醇。亚组分析显示，这种效应在女性中显著，而在男性中不显著。血清磷脂n - 3脂肪酸的增加与HDL2胆固醇的增加及收缩压的降低显著相关。
中等量的鱼油（6克/天）不太可能降低血压正常者的血压，但可能会增加HDL2胆固醇，尤其是在女性中。
