Maslov L N, Lishmanov Iu B
Biull Eksp Biol Med. 1988 Oct;106(10):408-10.
Ventricular fibrillation, caused by the occlusion of the anterior descending coronary artery, results in leu-enkephalin level decrease in ischemic and non-ischemic zones of myocardium. The fibrillation is found to induce cAMP increase in the ischemic zone and cGMP increase in the normal circulation zone. cGMP and leu-enkephalin level correlates with fibrillation duration. Enkephalins and cyclic nucleotides are suggestive of being of importance in heart rythm disturbances pathogenesis.
由前降支冠状动脉闭塞引起的心室颤动，会导致心肌缺血区和非缺血区亮脑啡肽水平降低。研究发现，颤动会导致缺血区环磷酸腺苷（cAMP）增加，正常循环区环磷酸鸟苷（cGMP）增加。cGMP和亮脑啡肽水平与颤动持续时间相关。脑啡肽和环核苷酸提示在心律失常的发病机制中具有重要作用。
