Zhao X, Fu W J, Yuan W J, Hou G X, Chen J G, Xia J H, Zhu H N
Department of Physiology, Second Military Medical University, Shanghai, China.
Zhongguo Yao Li Xue Bao. 1994 Jul;15(4):363-6.
The influence of endothelin-1 on ventricular fibrillation threshold was studied in acute myocardial ischemic rats. Endothelin-1 (1.5-3.0 micrograms.kg-1 i.v.) given 5 min before ischemia reduced the ventricular fibrillation threshold in a dose- and time-dependent manner. Its effect lasted at least 60 min. A marked increase of spontaneous ventricular tachycardia and myocardial infarct size was seen and the arterial blood pressure was at a higher level (18.5-20.1/14.4-15.8 kPa) after 3.0 micrograms.kg-1. Diltiazem prevented partially from reduction of ventricular fibrillation threshold, eliminated completely the vasopressor response and limited the extension of myocardial necrosis induced by endothelin-1.
研究了内皮素 -1 对急性心肌缺血大鼠心室颤动阈值的影响。在缺血前 5 分钟静脉注射内皮素 -1（1.5 - 3.0 微克·千克⁻¹），可呈剂量和时间依赖性降低心室颤动阈值。其作用至少持续 60 分钟。在给予 3.0 微克·千克⁻¹ 后，可见自发性室性心动过速明显增加、心肌梗死面积增大，且动脉血压处于较高水平（18.5 - 20.1/14.4 - 15.8 千帕）。地尔硫䓬部分预防了心室颤动阈值的降低，完全消除了升压反应，并限制了内皮素 -1 所致心肌坏死的扩展。
