Ivanov D E, Vitvitskiĭ V N
Vopr Med Khim. 1992 Mar-Apr;38(2):36-8.
Embryonal nervous tissue from Wistar rats was transplanted into male rats of Wistar and August strains. Activity of eight enzymes belonging to various systems was estimated in brain cortex of rats recipients within 36 days after the transplantation. Lactate dehydrogenase, alanine aminotransferase, acid phosphatase, 5'-nucleotidase, ATPase and aldolase exhibited the dissimilarly decreased rate of activity in brain cortex of Wistar rats after transplantation as compared with the enzymatic activity in intact animals of this strain, while activity of alkaline phosphatase and esterases hydrolyzing alpha-naphthyl acetate was increased. Activation of almost all the enzymes studied was found within 36 days in Wistar rats after the transplantation. The rate of activity of zonal esterase isoenzymes was higher in brain cortex of August rats after transplantation of embryonal nervous tissue from Wistar strain as compared with that of Wistar to Wistar rats transplantation. The data obtained suggest that tissues of donors affected definitely the enzymatic activity in brain cells of rats-recipients as activity of most enzymes studied was higher in brain cortex of donors as compared with that of recipients.
将来自Wistar大鼠的胚胎神经组织移植到Wistar和奥古斯特品系的雄性大鼠体内。在移植后36天内,对受体大鼠大脑皮层中属于不同系统的8种酶的活性进行了评估。与该品系未受损动物的酶活性相比,乳酸脱氢酶、丙氨酸转氨酶、酸性磷酸酶、5'-核苷酸酶、ATP酶和醛缩酶在Wistar大鼠移植后的大脑皮层中活性下降速率不同,而碱性磷酸酶和水解α-萘乙酸的酯酶活性增加。在Wistar大鼠移植后36天内发现几乎所有研究的酶都被激活。与Wistar大鼠之间的移植相比,将Wistar品系的胚胎神经组织移植到奥古斯特大鼠后,其大脑皮层中的区域酯酶同工酶活性更高。获得的数据表明,供体组织确实影响受体大鼠脑细胞中的酶活性,因为与受体相比,大多数研究酶的活性在供体大脑皮层中更高。