[Protein synthesis in cerebral cortex cells of rats exposed to hypoxia during interparenchymal administration of protein isolated from embryonal nerve tissue into the cerebral cortex].

The stage-specific activator protein CF was studied for effects on protein biosynthesis in the fractions rich in nerve and glial cells of the brain cortex of rats which had been exposed to hypoxia. Protein was isolated from the cortex of embryos or from the cerebellum of 8-10-day rats, the period being of the most active nerve cell proliferation. Following 4 days of the interparenchymal administration of SF into the cerebral cortex of the animals exposed to hypoxia there was an increase in the rate of 3-H-leucine incorporation into the nerve cells up to the values observed in the neurons of the cerebral cortex of intact animals. The level of protein synthesis in the glial cells remained unchanged. There were no increases in protein synthesis either in nerve or glial cells 120 days after single administration of SF. The findings were compared with the experimental evidence for the biosynthesis of macromolecules in various cerebral cortical cells from rats exposed to hypoxia and undergone transplantation of embryonal nerve tissue.