Flerov M A, Tolstukhina T I
Vopr Med Khim. 1992 Mar-Apr;38(2):40-3.
Metabolism of individual phospholipids was studied in neurones and neuroglia under conditions of convulsions caused by picrotoxin administration. Metabolic activity of all the phospholipids studied was increased in neuronal membranes under extreme conditions of convulsive attacks. The rate of metabolism of phosphatidylcholine, phosphatidylethanolamine and sphingomyelin was increased 2-2.5-fold approximately. The most distinct alterations of metabolic activity were observed in the fraction of minor phospholipids: specific radioactivity of phosphatidylserine was increased 10-fold and phosphatidylinositol--16-fold. Metabolism of phosphatidic acid and lysophosphatidylcholine was elevated more than 15-fold. Convulsions exhibited the most distinct effect on metabolism of phosphatidylinositol and phosphatidylserine in neuroglia cells. As distinct from neurones, metabolism of phosphatidyl choline and sphingomyelin was not markedly altered in neuroglia. Similar metabolism and universal cell response, carried out via phospholipids, appear to occur in the system neurone-neuroglia.
在给予印防己毒素引起惊厥的条件下，研究了神经元和神经胶质细胞中个别磷脂的代谢情况。在惊厥发作的极端条件下，神经元膜中所有研究的磷脂的代谢活性均增加。磷脂酰胆碱、磷脂酰乙醇胺和鞘磷脂的代谢速率大约增加了2至2.5倍。在次要磷脂部分观察到代谢活性最明显的变化：磷脂酰丝氨酸的比放射性增加了10倍，磷脂酰肌醇增加了16倍。磷脂酸和溶血磷脂酰胆碱的代谢升高了15倍以上。惊厥对神经胶质细胞中磷脂酰肌醇和磷脂酰丝氨酸的代谢表现出最明显的影响。与神经元不同，神经胶质细胞中磷脂酰胆碱和鞘磷脂的代谢没有明显改变。神经元-神经胶质细胞系统中似乎发生了通过磷脂进行的类似代谢和普遍的细胞反应。
