Woelk H
Pharmakopsychiatr Neuropsychopharmakol. 1979 May;12(3):251-6. doi: 10.1055/s-0028-1094617.
In the search for the biochemical basis of the action of Piracetam, the effects of this encephalotropic substance on the neuronal and glial phospholipid metabolism was investigated. Piracetam increases the incorporation of 32P into phosphatidylinositol and phosphatidyl choline of both glia and neuronal cell bodies (Figs. 1 and 2). When taking the important role of phosphatidylinositol in the processes of synaptic transmission and axonal conduction into consideration, the data obtained in the present work suggest that piracetam may stimulate excitatory neurons and may be involved in the process of synaptic transmission. The stimulatory effect of piracetam on the incorporation of 32P into phosphatidylinositol and phosphatidyl choline appears to be mediated by noerpinephrine or another neurotransmitter. Glial cells, isolated from the cerebral cortex of a rabbit, contained approximately one-third more phospholipids per uint protein than the neuronal cell bodies. The distribution and pattern of phospholipid relative to the total amount, was rather similar in both cell types. The incorporation of 32P into phosphatidylinositol and phosphatidyl choline was somewhat faster in neurons than in glial cells. Compared to glial cells the neuronal cell fraction had a higher phospholipid turnover.
在寻找吡拉西坦作用的生化基础过程中，研究了这种亲脑性物质对神经元和神经胶质磷脂代谢的影响。吡拉西坦增加了32P掺入神经胶质细胞和神经元细胞体的磷脂酰肌醇和磷脂酰胆碱中的量（图1和图2）。考虑到磷脂酰肌醇在突触传递和轴突传导过程中的重要作用，本研究获得的数据表明，吡拉西坦可能刺激兴奋性神经元，并可能参与突触传递过程。吡拉西坦对32P掺入磷脂酰肌醇和磷脂酰胆碱的刺激作用似乎是由去甲肾上腺素或另一种神经递质介导的。从兔大脑皮层分离的神经胶质细胞，每单位蛋白质所含的磷脂比神经元细胞体多约三分之一。两种细胞类型中磷脂相对于总量的分布和模式相当相似。32P掺入磷脂酰肌醇和磷脂酰胆碱的速度在神经元中比在神经胶质细胞中稍快。与神经胶质细胞相比，神经元细胞部分的磷脂周转率更高。
