磷化氢与血红蛋白及红细胞的相互作用。
The interaction of phosphine with haemoglobin and erythrocytes.
作者信息
Chin K L, Mai X, Meaklim J, Scollary G R, Leaver D D
机构信息
Department of Pharmacology, University of Melbourne, Parkville, Australia.
出版信息
Xenobiotica. 1992 May;22(5):599-607. doi: 10.3109/00498259209053123.
PMID:1413875
Abstract
- Phosphine progressively converts oxyhaemoglobin to methaemoglobin and hemichrome species, with the product formed being time- and concentration-dependent. 2. The reaction of phosphine with oxyhaemoglobin leads to the formation of phosphite and phosphate. 3. Incubation of rat erythrocytes with various concentrations of phosphine results in the progressive uptake of phosphine by the erythrocytes in a temperature-dependent first-order process. 4. Uptake of phosphine by erythrocytes causes crenation, but conversion of oxyhaemoglobin to methaemoglobin and hemichrome could not be demonstrated.
摘要
- 磷化氢会逐渐将氧合血红蛋白转化为高铁血红蛋白和半色素物质，其生成的产物与时间和浓度有关。2. 磷化氢与氧合血红蛋白的反应会导致亚磷酸盐和磷酸盐的形成。3. 用不同浓度的磷化氢孵育大鼠红细胞，会使红细胞以温度依赖的一级过程逐渐摄取磷化氢。4. 红细胞摄取磷化氢会导致细胞皱缩，但无法证明氧合血红蛋白会转化为高铁血红蛋白和半色素。
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