尿毒症滤液中的一种新的卡马西平代谢物。
A new carbamazepine metabolite in uraemic filtrate.
作者信息
Beyer C, Spiteller G
机构信息
Lehrstuhl Organische Chemie I, Universität Bayreuth, Germany.
出版信息
Xenobiotica. 1992 Aug;22(8):1029-35. doi: 10.3109/00498259209049908.
PMID:1413879
Abstract
- After administration of carbamazepine (Tegretal) to an epileptic patient suffering also from uraemia, a previously unknown metabolite was detected in the haemofiltrate. It was identified as the 10,11-dihydro-10-hydroxy-carbamazepine-O-beta-glucuronide. 2. Its identification was accomplished mainly by electron impact (EI), liquid secondary ion (LSI) mass spectrometry and n.m.r. spectroscopy.
摘要
- 给一名同时患有尿毒症的癫痫患者服用卡马西平（ Tegretal）后，在血液滤过液中检测到一种先前未知的代谢物。它被鉴定为10,11-二氢-10-羟基卡马西平-O-β-葡萄糖醛酸苷。2. 其鉴定主要通过电子轰击（EI）、液体二次离子（LSI）质谱和核磁共振光谱完成。
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