二茂金属的生物化学。乙酰钌二茂的主要代谢物的鉴定。
Biochemistry of metallocenes. Identification of the major metabolite of acetylruthenocene.
作者信息
Taylor A J, Wenzel M
出版信息
Biochem J. 1978 Apr 15;172(1):77-82. doi: 10.1042/bj1720077.
Abstract
- After oral administration of acetylruthenocene to rats, metabolites were detected in bile and urine. 2. The major metabolite, which is present in both bile and urine, is a glucuronide with the structure: C5H5-Ru-C5H4-CO-CH2-O-C6H9O6 3. The metabolite was identified by mass spectrometry of the permethylated glucuronide and mass spectrometry and n.m.r. of the aglycone. 4. The nature of the metabolite is discussed, and a comparison is made with the metabolism of the benzene analogue, acetophenone.
摘要
- 给大鼠口服乙酰钌茂后，在胆汁和尿液中检测到了代谢产物。2. 胆汁和尿液中均存在的主要代谢产物是一种具有以下结构的葡糖醛酸苷：C5H5-Ru-C5H4-CO-CH2-O-C6H9O6 3. 通过对全甲基化葡糖醛酸苷进行质谱分析以及对苷元进行质谱分析和核磁共振鉴定了该代谢产物。4. 讨论了该代谢产物的性质，并与苯类似物苯乙酮的代谢进行了比较。
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