药用植物对造血细胞的影响。
Effects of medicinal plants on hemopoietic cells.
作者信息
Ikehara S, Kawamura H, Komatsu Y, Yamada H, Hisha H, Yasumizu R, Ohnishi-Inoue Y, Kiyohara H, Hirano M, Aburada M
机构信息
1st Department of Pathology, Kansai Medical University, Osaka, Japan.
出版信息
Adv Exp Med Biol. 1992;319:319-30. doi: 10.1007/978-1-4615-3434-1_32.
It has been found that Juzentaihoto (TJ-48), one of the traditional Japanese kampo (herbal) medicines, improves the general condition of cancer patients receiving chemotherapy and radiation therapy. We analyze how TJ-48 elicits such effect, and show that oral administration of TJ-48 accelerates recovery from hemopoietic injury induced by radiation and the anti-cancer drug mitomycin C. The effects are found to be due to its stimulation of spleen colony-forming units. Based on the present findings, we propose that the administration of TJ-48 should be of benefit to patients receiving chemotherapy, radiation therapy or bone marrow transplantation.
已发现，传统日本汉方（草药）药物之一的十全大补汤（TJ - 48）可改善接受化疗和放疗的癌症患者的总体状况。我们分析了TJ - 48如何产生这种效果，并表明口服TJ - 48可加速由辐射和抗癌药物丝裂霉素C引起的造血损伤的恢复。发现这些效果是由于其对脾集落形成单位的刺激。基于目前的研究结果，我们认为给予TJ - 48对接受化疗、放疗或骨髓移植的患者有益。
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