Prospects for cardioreparation.

The structure of the myocardium has 2 principal components, a myocytic compartment and a non-myocytic compartment that consists primarily of interstitial tissue. It appears that increased collagen production is mainly responsible for the functional consequences of structural remodelling. The concept of cardioreparation implies both a restoration of structural abnormalities and a return of cardiac function to or toward normal. In spontaneously hypertensive rats with left ventricular hypertrophy and adverse structural remodeling of the cardiac interstitium, angiotensin-converting enzyme inhibition has resulted in restoration of myocardial integrity and stiffness toward normal. Further research needs to be undertaken to identify the molecular mechanisms involved in the development of interstitial myocardial fibrosis, and reliable methods for assessing the interstitium and the changes that occur within it in clinical practice need to be developed.