Rannem T, Ladefoged K, Hylander E, Hegnhøj J, Jarnum S
Medical Department A, Rigshospitalet, Copenhagen, Denmark.
Am J Clin Nutr. 1992 Nov;56(5):933-7. doi: 10.1093/ajcn/56.5.933.
Twenty-seven of 66 patients with Crohn's disease had reduced concentrations of selenium and glutathione peroxidase in plasma and erythrocytes. When the patients were subgrouped according to the length of resected small bowel, a significant reduction of selenium and glutathione peroxidase in both plasma and erythrocytes was only found in patients with a resection > 200 cm. A highly significant correlation between selenium and glutathione peroxidase was found in plasma (r = 0.81) as well as in erythrocytes (r = 0.62), but no correlation was observed in the control group. A statistically significant correlation was also found between plasma selenium and the Harvey-Bradshaw score (r = -0.44), body mass index (wt/ht2) (r = 0.47), and plasma albumin (r = 0.29). Patients with a small-bowel resection > 200 cm appear to be at risk of developing severe selenium deficiency. These patients should have their selenium status monitored and probably receive selenium supplementation.
66例克罗恩病患者中，有27例血浆和红细胞中的硒及谷胱甘肽过氧化物酶浓度降低。根据切除的小肠长度对患者进行亚组分析时，仅在切除长度>200 cm的患者中发现血浆和红细胞中的硒及谷胱甘肽过氧化物酶显著降低。血浆（r = 0.81）和红细胞（r = 0.62）中硒与谷胱甘肽过氧化物酶之间存在高度显著相关性，但在对照组中未观察到相关性。血浆硒与哈维-布拉德肖评分（r = -0.44）、体重指数（体重/身高²）（r = 0.47）和血浆白蛋白（r = 0.29）之间也存在统计学显著相关性。小肠切除长度>200 cm的患者似乎有发生严重硒缺乏的风险。这些患者应监测其硒状态，并可能需要补充硒。
