温和噬菌体在A组链球菌产生致热外毒素中的作用
THE ROLE OF TEMPERATE BACTERIOPHAGE IN THE PRODUCTION OF ERYTHROGENIC TOXIN BY GROUP A STREPTOCOCCI.
作者信息
ZABRISKIE J B
出版信息
J Exp Med. 1964 May 1;119(5):761-80. doi: 10.1084/jem.119.5.761.
Abstract
Non-lysogenic, non-toxinogenic Group A streptococci when infected by temperate bacteriophages isolated from known scarlatinal toxin-producing strains acquire the capacity to form erythrogenic toxin. This toxin causes a characteristic erythematous reaction in the skin of rabbits and is readily neutralizable by standard scarlatinal antitoxins. The production of toxin appears to be related to the synthesis of mature phage particles since ultraviolet enhancement of phage production results in a concomitant increase in toxin titer. In contrast, there is no increase in the production of another extracellular product, deoxyribonuclease, by these lysogenized streptococci. Furthermore, cellular disruption studies indicate that the toxin probably does not exist in a preformed state within the cell. Double diffusion reactions in agar indicate that a newly formed protein appears in the lysogenic culture filtrate and is absent in the non-lysogenic filtrates.
摘要
当从已知能产生猩红热毒素的菌株中分离出的温和噬菌体感染非溶原性、不产生毒素的A组链球菌时，这些链球菌就获得了形成红斑毒素的能力。这种毒素会在兔皮肤上引起典型的红斑反应，并且很容易被标准的猩红热抗毒素中和。毒素的产生似乎与成熟噬菌体颗粒的合成有关，因为噬菌体产量的紫外线增强会导致毒素效价随之增加。相比之下，这些溶原化的链球菌产生的另一种细胞外产物——脱氧核糖核酸酶的产量并没有增加。此外，细胞破碎研究表明，毒素可能并非以预先形成的状态存在于细胞内。琼脂中的双向扩散反应表明，溶原性培养滤液中出现了一种新形成的蛋白质，而非溶原性滤液中则没有这种蛋白质。
相似文献
1
THE ROLE OF TEMPERATE BACTERIOPHAGE IN THE PRODUCTION OF ERYTHROGENIC TOXIN BY GROUP A STREPTOCOCCI.
J Exp Med. 1964 May 1;119(5):761-80. doi: 10.1084/jem.119.5.761.
2
Phage influence on the synthesis of extracellular toxins in group A streptococci.
Infect Immun. 1982 May;36(2):745-50. doi: 10.1128/iai.36.2.745-750.1982.
3
Phage-host interactions and the production of type A streptococcal exotoxin in group A streptococci.
Infect Immun. 1981 Dec;34(3):915-9. doi: 10.1128/iai.34.3.915-919.1981.
4
HOST-PARASITE RELATIONSHIPS AMONG GROUP A STREPTOCOCCI. 3. DEPRESSION OF RETICULOENDOTHELIAL FUNCTION BY STREPTOCOCCAL PYROGENIC EXOTOXINS.
J Bacteriol. 1965 Jan;89(1):154-8. doi: 10.1128/jb.89.1.154-158.1965.
5
In vivo lysogenic conversion of Tox(-) Streptococcus pyogenes to Tox(+) with Lysogenic Streptococci or free phage.
Infect Immun. 2003 Jul;71(7):3782-6. doi: 10.1128/IAI.71.7.3782-3786.2003.
6
[Isolation and characterization of erythrogenic toxins. VII. Study of the erythrogenic toxin type C produced by Streptococcus pyogenes].
Zentralbl Bakteriol Mikrobiol Hyg A. 1984 May;257(1):38-50.
7
Induction of lysogenic bacteriophage and phage-associated toxin from group a streptococci during coculture with human pharyngeal cells.
Infect Immun. 2001 Mar;69(3):1440-3. doi: 10.1128/IAI.69.3.1440-1443.2001.
8
Streptococcal L forms and phage. A clinical-epidemiologic study.
Yale J Biol Med. 1974;47(2):86-92.
9
[Identification of the gene of type A erythrogenic toxin in strains of group A Streptococcus].
Vestn Akad Med Nauk SSSR. 1989(11):59-62.
10
Erythrogenic toxins A, B and C: occurrence of the genes and exotoxin formation from clinical Streptococcus pyogenes strains associated with streptococcal toxic shock-like syndrome.
FEMS Microbiol Lett. 1992 Dec 15;100(1-3):313-22. doi: 10.1111/j.1574-6968.1992.tb14058.x.
引用本文的文献
1
A dynamic subpopulation of CRISPR-Cas overexpressers allows Streptococcus pyogenes to rapidly respond to phage.
Nat Microbiol. 2024 Sep;9(9):2410-2421. doi: 10.1038/s41564-024-01748-0. Epub 2024 Jul 12.
2
Challenges of bacteriophages application in controlling bacterial plant diseases and how to overcome them.
J Genet Eng Biotechnol. 2023 Oct 10;21(1):98. doi: 10.1186/s43141-023-00549-y.
3
Conjugative transfer of streptococcal prophages harboring antibiotic resistance and virulence genes.
ISME J. 2023 Sep;17(9):1467-1481. doi: 10.1038/s41396-023-01463-4. Epub 2023 Jun 27.
4
The Bacteriophages of .
Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.GPP3-0059-2018.
5
Development of Phage Lysins as Novel Therapeutics: A Historical Perspective.
Viruses. 2018 Jun 7;10(6):310. doi: 10.3390/v10060310.
6
Toward Understanding Phage:Host Interactions in the Rumen; Complete Genome Sequences of Lytic Phages Infecting Rumen Bacteria.
Front Microbiol. 2017 Dec 5;8:2340. doi: 10.3389/fmicb.2017.02340. eCollection 2017.
7
Transcriptional regulation of a bacteriophage encoded extracellular DNase (Spd-3) by Rgg in Streptococcus pyogenes.
PLoS One. 2013 Apr 17;8(4):e61312. doi: 10.1371/journal.pone.0061312. Print 2013.
8
Glycerol monolaurate antibacterial activity in broth and biofilm cultures.
PLoS One. 2012;7(7):e40350. doi: 10.1371/journal.pone.0040350. Epub 2012 Jul 11.
9
Lysogenic transfer of mef(A) and tet(O) genes carried by Phim46.1 among group A streptococci.
Antimicrob Agents Chemother. 2010 Oct;54(10):4464-6. doi: 10.1128/AAC.01318-09. Epub 2010 Jul 19.
10
Lysogenic transfer of group A Streptococcus superantigen gene among Streptococci.
J Infect Dis. 2008 Jan 15;197(2):225-34. doi: 10.1086/524687.
本文引用的文献
1
TYPING GROUP A HEMOLYTIC STREPTOCOCCI BY M PRECIPITIN REACTIONS IN CAPILLARY PIPETTES.
J Exp Med. 1943 Aug 1;78(2):127-33. doi: 10.1084/jem.78.2.127.
2
The occurrence of nucleases in culture filtrates of group A hemolytic streptococci.
J Exp Med. 1948 Aug;88(2):181-8. doi: 10.1084/jem.88.2.181.
3
The crystallization and serological differentiation of a streptococcal proteinase and its precursor.
J Exp Med. 1950 Sep;92(3):201-18. doi: 10.1084/jem.92.3.201.
4
Further observations on the change to virulence of bacteriophage-infected a virulent strains of Corynebacterium diphtheria.
J Bacteriol. 1952 Mar;63(3):407-14. doi: 10.1128/jb.63.3.407-414.1952.
5
Replica plating and indirect selection of bacterial mutants.
J Bacteriol. 1952 Mar;63(3):399-406. doi: 10.1128/jb.63.3.399-406.1952.
6
Studies on streptococcal bacteriophages. 5. Serological investigation of phages isolated from 91 strains of group A haemolytic streptococci.
Acta Pathol Microbiol Scand. 1960;49:205-12.
7
Studies on streptococcal bacteriophages. 4. The occurrence of lysogenic strains among group A haemolytic streptococci.
Acta Pathol Microbiol Scand. 1960;49:199-204.
8
Studies on streptococcal bacteriophages. I. Technique of isolating phage-producing strains.
Acta Pathol Microbiol Scand. 1955;36(5):433-40.
9
The use of precipitin analysis in agar for the study of human streptococcal infections. IV. Further observations on the purification of group A extracellular antigens.
J Exp Med. 1961 Jan 1;113(1):131-58. doi: 10.1084/jem.113.1.131.
10
Toxinogeny in Corynebacterium diphtheriae.
J Bacteriol. 1961 Apr;81(4):527-40. doi: 10.1128/jb.81.4.527-540.1961.
Zotero 插件