Byshovets S N, Treshchinskiĭ A I
Anesteziol Reanimatol. 1992 Mar-Apr(2):7-9.
Twenty five female patients (3 groups) operated on for cholelithiasis without premedication have been examined. In patients of group F an effective flormidal dose (EFD) causing an unconscious state upon intravenous injection by a measuring device has been determined. Due to an insufficient sedative effect of moradol it was impossible to determine an effective moradol dose (EMD). In group M+F right after intravenous administration of a standard moradol dose (SMD) flormidal infusion was begun, as in patients of group F. EFD after moradol injection (EFMD) was determined. Making proportions with known EFD, EFMD and SMD values, EMD was calculated. Upon intravenous administration of the calculated EMD by a measuring device the sedative effect was superficial in all the patients of group M and it was impossible to achieve an unconscious state. The interaction of moradol (butorphanol tartrate) and flormidal (midazolam) in the patients' body is of synergic nature.
对25例未进行术前用药就接受胆石症手术的女性患者（3组）进行了检查。在F组患者中，使用测量装置确定了静脉注射时能导致无意识状态的有效氟米达剂量（EFD）。由于吗多明的镇静效果不足，无法确定有效吗多明剂量（EMD）。在M+F组中，与F组患者一样，在静脉注射标准吗多明剂量（SMD）后立即开始氟米达输注，并确定吗多明注射后的EFD（EFMD）。通过已知的EFD、EFMD和SMD值进行比例计算，得出EMD。通过测量装置静脉注射计算出的EMD后，M组所有患者的镇静效果都很轻微，无法达到无意识状态。吗多明（酒石酸布托啡诺）和氟米达（咪达唑仑）在患者体内的相互作用具有协同性质。
