Avrutskiĭ M Ia, Shiriaev V S, Machulin A V
Anesteziol Reanimatol. 1990 Jul-Aug(4):38-42.
A technique is described for the use of moradol as an agent ensuring analgesia in modern combined general anesthesia during abdominal and thoracic surgery, cardiac surgery, cardiopulmonary bypass included, and diagnostic manipulations. Moradol was particularly effective for long-term surgery. The drug was also useful for premedication (0.06 mg/kg) and needed no combination with any tranquilizers or analgesics. Agonist opioid activity of moradol was maximum 10 min after its intravenous administration, therefore a 5 to 10 min exposition upon moradol injection prior to hypnotic drug administration is suggested. Bolus drug dose (150 mg/kg) for induction to anesthesia was an adequate protection against pain impulsation in surgical trauma in the course of 3-4 hours of surgical intervention.
本文描述了一种使用吗多明作为确保在腹部和胸部手术、心脏手术（包括体外循环）及诊断操作的现代联合全身麻醉中实现镇痛的药物的技术。吗多明在长期手术中特别有效。该药物用于术前用药（0.06mg/kg）也很有用，且无需与任何镇静剂或镇痛药联合使用。吗多明的激动型阿片样物质活性在静脉给药后10分钟达到最大值，因此建议在给予催眠药物前注射吗多明后进行5至10分钟的暴露。诱导麻醉的大剂量药物（150mg/kg）在3至4小时的手术干预过程中能充分保护免受手术创伤中的疼痛冲动。
