McLennan H, Gilfillan Karen, Heap Yvonne
Department of Physiology, University of British Columbia, Vancouver, B.C. 1W5 Canada.
Pain. 1977 Jun;3(3):229-238. doi: 10.1016/0304-3959(77)90004-5.
(1) The characteristics of an analgesia which can be elicited in rabbits by electrically activated acupuncture needles are described. (2) The analgesia can be reversed by systemic administration of the inhibitory amino acid antagonists bicuculline or strychnine. (3) Pharmacological procedures which interfere with tryptaminergic mechanisms, or destruction of the dorsal raphe nuclei, prevent the development of analgesia. (4) It is concluded that the production of analgesia probably depends upon postsynaptic inhibition of the transmission of afferent information from nociceptors, and at more than one site in the central nervous system.
（1）本文描述了电刺激兔体上的针灸针所引发的镇痛作用的特征。（2）全身性给予抑制性氨基酸拮抗剂荷包牡丹碱或士的宁可使这种镇痛作用逆转。（3）干扰色胺能机制的药理学方法或损毁中缝背核会阻止镇痛作用的产生。（4）得出的结论是，镇痛作用的产生可能依赖于对伤害感受器传入信息传递的突触后抑制，且发生在中枢神经系统的多个部位。
