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[耳穴电刺激与纳洛酮对家兔伤害性感受敏感性的影响]

[Effects of auricular electrostimulation and naloxone on nociceptive sensitivity in rabbits].

作者信息

Raevskaia O S, Grishanin G G

出版信息

Biull Eksp Biol Med. 1990 Oct;110(10):339-41.

PMID:2279075
Abstract

Auriculo-acupuncture electrostimulation (AES) (15 H2) decreased the amplitude of somatosensory evoked potential (EP) in response to tooth pulp electrostimulation in 64% of acupuncture-sensitive unanesthetized rabbits and didn't induce the changes of EP in 36% of animals (acupuncture-resistant rabbits). The systemic naloxone (0.2 mg/kg) injection reversed the AES analgetic effect and induced the hyperalgesic one in acupuncture-sensitive rabbits but induced the analgetic effect in acupuncture-resistant animals. It has been suggested that the differences of individual characteristics of endogenous opioid system determined different naloxone action in acupuncture-sensitive and acupuncture-resistant rabbits.

摘要

耳针电刺激(AES)(15赫兹)可使64%对针刺敏感的未麻醉家兔在牙髓电刺激时体感诱发电位(EP)的波幅降低,而在36%的动物(针刺耐受家兔)中未引起EP变化。全身注射纳洛酮(0.2毫克/千克)可逆转AES的镇痛作用,并在针刺敏感家兔中诱发痛觉过敏,但在针刺耐受动物中诱发镇痛作用。有人提出,内源性阿片系统个体特征的差异决定了纳洛酮在针刺敏感和针刺耐受家兔中的不同作用。

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